Excellence in Research and Innovation for Humanity

International Science Index


Select areas to restrict search in scientific publication database:
1020
Biomass and Pigment Production by Monascus during Miniaturized Submerged Culture on Adlay
Abstract:
Three reactor types were explored and successfully used for pigment production by Monascus: shake flasks, and shaken and stirred miniaturized reactors. Also, the use of dielectric spectroscopy for the on-line measurement of biomass levels was explored. Shake flasks gave good pigment yields, but scale up is difficult, and they cannot be automated. Shaken bioreactors were less successful with pigment production than stirred reactors. Experiments with different impeller speeds in different volumes of liquid in the reactor confirmed that this is most likely due oxygen availability. The availability of oxygen appeared to affect biomass levels less than pigment production; red pigment production in particular needed very high oxygen levels. Dielectric spectroscopy was effectively used to continuously measure biomass levels during the submerged fungal fermentation in the shaken and stirred miniaturized bioreactors, despite the presence of the solid substrate particles. Also, the capacitance signal gave useful information about the viability of the cells in the culture.

References:

[1] S.-W. Chiu, "Submerge production of Monascus pigments," Mycologia, vol. 85, 214-218, 1993.
[2] L. Dufossé, P. Galaup, A. Yaron, S. M. Arad, P. B. Kotamalli, K. N. C. Murthy and G. A. Ravishankar, "Microorganisms and microalgae as sources of pigments for food use: a scientific oddity or an industrial reality," Trends in Food Science & Technology vol. 16, pp. 389-406, 2005.
[3] J. H. Yang, Y. Tseng, H. Chang, Y. Lee and J. Mau, "Storage stability of monascal adlay," Food Chemistry, vol. 90, pp. 303-309, 2004.
[4] P. J┼»zlov├í, L. Mart├¡nkov├í and V. Křen, "Secondary metabolites of the fungus Monascus: review," Journal of Industrial Microbiology, vol. 16, pp. 163-170, 1996.
[5] T. H. Wang, and T. F. Lin, "Monascus rice products," Advances in Food and Nutrition Research, vol. 53, pp.123-159, 2007.
[6] U. Hölker, M. Höfer and J. Lenz, "Biotechnological advantages of laboratory-scale solid-state fermentation with fungi," Applied Microbiology Biotechnology, vol. 64, pp. 175-186, 2004.
[7] R. R. Singhania, A. K. Patel, C. R. Soccol and A. Pandey, "Recent advance in solid state fermentation," Biochemical Engineering Journal, vol. 44, pp.13-18, 2009.
[8] J. I. Betts and F. Baganz, "Miniature bioreactors: current practices and future opportunities," Microbiol Cell Factories, vol. 5, pp. 1-14, 2006.
[9] W.A. Duetz, "Microtiter plates as mini-bioreactors: miniaturization of fermentation methods," Trends in Microbiology, vol. 15, pp. 469 - 475, 2007.
[10] V. Hessel, C. Knobloch and H. Löwe, "Review on patents in microreactor and micro process engineering," Recent Patents on Chemical Engineering, vol. 1, pp. 1-16. , 2008.
[11] S. R. Lamping, H. Zhang, B. Allen and P. A. Shamlou, "Design of a prototype miniature bioreactor for high throughput automated bioprocessing," Chemical Engineering Science, vol. 58, pp. 747-758, 2003.
[12] M. Micheletti, and G. J. Lye, "Microscale bioprocess optimisation, "Current Opinion in Biotechnology, vol. 17, pp. 611-618, 2006.
[13] D. Weuster-Botz, S. Stevensb and A. Hawrylenkoc, "Parallel-operated stirred-columns for microbial process development," Biochemical Engineering Journal, vol. 11, pp. 69-72, 2002.
[14] U. v. Stockar, S. Valentinotti, I. Marison, C. Cannizzaro and C. Herwig, "Know-how and know-why in biochemical engineering," Biotechnology Advance, vol. 21, 417-430, 2003.
[15] R. Fehrenbach, M. Comberbach and J. O. Pêtre, "On-line biomass monitor by capacitance measurement," Journal of Biotechnology vol. 23, pp. 303-314, 1992.
[16] R. M. Matanguihan and K. B. Konstantinov and T. Yoshida, "Dielectric measurement to monitor the growth and physiological states of biological cells," Bioprocess Engineering, vol. 11, pp. 213-222, 1994.
[17] W. Penaloza, C. L. Davey, J. N. Hedger and D. B. Kell, "Stimulation by potassium of the growth of Rhizopus oligosporus during liquid- and solid-substrate fermentations," World Journal of Microbiology and Biotechnolpgy, vol 7, pp. 260-268, 1991.
[18] K. Mishima, A. Mimura, Y. Takahara, K. Asami and T. Hanai, "On-line monitor of cell concentrations by dielectric measurements," Journal of Fermentation and Bioengineering, vol. 72, pp. 291-295, 1991.
[19] X. Lian, C. Wang and K. Guo, "Identification of new red pigments produced by Monascus ruber," Dyes and Pigments, vol. 73, pp. 121-125, 2007.
[20] S. T. Silveira, D. J. Daroit, and A. Brandelli , "Pigment production by Monascus purpureus in grape waste using factorial design," LWT-Food Science and Technology, vol. 41, pp.170-174, 2007.
[21] H. J. Kim, J. H. Kim, H. J. Oh and C. S. Shin, "Morphology control of Monascus cells and scale-up of pigment fermentation," Process Biochemistry, vol.38 pp. 649-655, 2002.
[22] P. Pattangul, R. Pinthong, A. Phianmongkhol and S. Tharatha, "Mevinolin, citrinin and pigments of adlay angkak fermented by Monascus sp.," International Journal of Food Microbiology, vol. 126, pp. 20-23, 2008.
[23] B. Yongsmith, V. Kitprechavanich, L. Chitradon, C. Chaisrisook, and N. Budda, "Color mutants of Monascus sp. KB9 and their comparative glucosamylases on rice solid culture," Journal of Molecular Catalysis B: Enzymatic, vol. 10, pp.263-272, 2000.
[24] S. Babitha, C. R. Soccol, and A. Pandey, "Solid-state fermentation for the production of Monascus pigments from jackfruit seed," Bioresource and Technology, vol. 98, pp. 1554-1560, 2007.
[25] W. Kloeckner, and J. Buchs, "Advances in shaking technologies," Trends in Microbiology, vol. 30, pp.-307-313, 2012.
[26] M. Micheletti, and G. J. Lye, "Microscale bioprocess optimization." Current Opinion in Biotechnology, vol. 17, pp.611-618, 2006.
[27] G.H. Markx, H. J. G. ten Hoopen, J. J. Meijer, and K. L. Vinke, "Dielectric spectroscopy as a novel and convenient tool for the study of the shear sensitivity of plant cells in suspension culture," Journal of Biotechnology, vol. 19, pp. 145-158, 1991.
[28] H. J. Kim, J.H. Kim, H. J. Oh, and C. S. Shin, "Morphology control of Monascus cells and scale-up of pigment fermentation," Process Biochemistry vol. 38, pp 649-655, 2002.
Vol:11 No:10 2017Vol:11 No:09 2017Vol:11 No:08 2017Vol:11 No:07 2017Vol:11 No:06 2017Vol:11 No:05 2017Vol:11 No:04 2017Vol:11 No:03 2017Vol:11 No:02 2017Vol:11 No:01 2017
Vol:10 No:12 2016Vol:10 No:11 2016Vol:10 No:10 2016Vol:10 No:09 2016Vol:10 No:08 2016Vol:10 No:07 2016Vol:10 No:06 2016Vol:10 No:05 2016Vol:10 No:04 2016Vol:10 No:03 2016Vol:10 No:02 2016Vol:10 No:01 2016
Vol:9 No:12 2015Vol:9 No:11 2015Vol:9 No:10 2015Vol:9 No:09 2015Vol:9 No:08 2015Vol:9 No:07 2015Vol:9 No:06 2015Vol:9 No:05 2015Vol:9 No:04 2015Vol:9 No:03 2015Vol:9 No:02 2015Vol:9 No:01 2015
Vol:8 No:12 2014Vol:8 No:11 2014Vol:8 No:10 2014Vol:8 No:09 2014Vol:8 No:08 2014Vol:8 No:07 2014Vol:8 No:06 2014Vol:8 No:05 2014Vol:8 No:04 2014Vol:8 No:03 2014Vol:8 No:02 2014Vol:8 No:01 2014
Vol:7 No:12 2013Vol:7 No:11 2013Vol:7 No:10 2013Vol:7 No:09 2013Vol:7 No:08 2013Vol:7 No:07 2013Vol:7 No:06 2013Vol:7 No:05 2013Vol:7 No:04 2013Vol:7 No:03 2013Vol:7 No:02 2013Vol:7 No:01 2013
Vol:6 No:12 2012Vol:6 No:11 2012Vol:6 No:10 2012Vol:6 No:09 2012Vol:6 No:08 2012Vol:6 No:07 2012Vol:6 No:06 2012Vol:6 No:05 2012Vol:6 No:04 2012Vol:6 No:03 2012Vol:6 No:02 2012Vol:6 No:01 2012
Vol:5 No:12 2011Vol:5 No:11 2011Vol:5 No:10 2011Vol:5 No:09 2011Vol:5 No:08 2011Vol:5 No:07 2011Vol:5 No:06 2011Vol:5 No:05 2011Vol:5 No:04 2011Vol:5 No:03 2011Vol:5 No:02 2011Vol:5 No:01 2011
Vol:4 No:12 2010Vol:4 No:11 2010Vol:4 No:10 2010Vol:4 No:09 2010Vol:4 No:08 2010Vol:4 No:07 2010Vol:4 No:06 2010Vol:4 No:05 2010Vol:4 No:04 2010Vol:4 No:03 2010Vol:4 No:02 2010Vol:4 No:01 2010
Vol:3 No:12 2009Vol:3 No:11 2009Vol:3 No:10 2009Vol:3 No:09 2009Vol:3 No:08 2009Vol:3 No:07 2009Vol:3 No:06 2009Vol:3 No:05 2009Vol:3 No:04 2009Vol:3 No:03 2009Vol:3 No:02 2009Vol:3 No:01 2009
Vol:2 No:12 2008Vol:2 No:11 2008Vol:2 No:10 2008Vol:2 No:09 2008Vol:2 No:08 2008Vol:2 No:07 2008Vol:2 No:06 2008Vol:2 No:05 2008Vol:2 No:04 2008Vol:2 No:03 2008Vol:2 No:02 2008Vol:2 No:01 2008
Vol:1 No:12 2007Vol:1 No:11 2007Vol:1 No:10 2007Vol:1 No:09 2007Vol:1 No:08 2007Vol:1 No:07 2007Vol:1 No:06 2007Vol:1 No:05 2007Vol:1 No:04 2007Vol:1 No:03 2007Vol:1 No:02 2007Vol:1 No:01 2007