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Commenced in January 2007 Frequency: Monthly Edition: International Publications Count: 29209

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MiRNAs as Regulators of Tumour Suppressor Expression
Tumour suppressors are key participants in the prevention of cancer. Regulation of their expression through miRNAs is important for comprehensive translation inhibition of tumour suppressors and elucidation of carcinogenesis mechanisms. We studies the possibility of 1521 miRNAs to bind with 873 mRNAs of human tumour suppressors using RNAHybrid 2.1 and ERNAhybrid programmes. Only 978 miRNAs were found to be translational regulators of 812 mRNAs, and 61 mRNAs did not have any miRNA binding sites. Additionally, 45.9% of all miRNA binding sites were located in coding sequences (CDSs), 33.8% were located in 3' untranslated region (UTR), and 20.3% were located in the 5'UTR. MiRNAs binding with more than 50 target mRNAs and mRNAs binding with several miRNAs were selected. Hsa-miR-5096 had 15 perfectly complementary binding sites with mRNAs of 14 tumour suppressors. These newly indentified miRNA binding sites can be used in the development of medicines (anti-sense therapies) for cancer treatment.
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[1] A. Chow, C.L. Arteaga, S.E. Wang, "When tumor suppressor TGFβ meets the HER2 (ERBB2) oncogene", J Mammary Gland Biol Neoplasia, vol. 2, no. 16, pp. 81-8. 2011.
[2] A. Andersen, D.A. Jones, "APC and DNA Demethylation in Cell Fate Specification and Intestinal Cancer", Adv Exp Med Biol, no. 754, pp. 167-77. 2013.
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[4] M. Ul Hussain, "Micro-RNAs (miRNAs): genomic organisation, biogenesis and mode of action", Cell Tissue Res, vol. 2, no. 349, pp. 405-13. 2012.
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