Scholarly Research Excellence
@article{(International Science Index):http://waset.org/publications/10002875,
  title    = {Phytochemical Screening, Antioxidant Activity and Lipid Profile Effects of Citrus reticulata Fruit Peel, Zingiber officinale Rhizome and Sesamum indicum Seed Extracts},
  author    = {Samar Saadeldin Abdelmotalab Omer and  Ikram Mohamed Eltayeb Elsiddig and  Amna Beshir Medani Ahmed and  Saad Mohamed Hussein Ayoub},
  country   = {Sudan},
  institution={University of Medical Sciences and Technology},
  abstract  = {Many herbal medicinal products are considered
potential anti-hypercholesterolemic agents with encouraging safety
profiles, however only a limited amount of clinical research exists to
support their efficacy. The present study was designed to compare the
antihypercholesterolemic and antioxidant activities of the crude
ethanolic extracts of Citrus reticulata fruit peel, Zingiber officinale
rhizome and Sesamum indicum seeds. Forty-five rats were used throughout the experiment which are
extended for four weeks. These were divided into nine groups, five
rats per each group as follows; group 1 was the normal control group
(rats only fed standard normal rat diet), group 2 was the
hypercholesterolemic control group (rats fed only
hypercholesterolemic diet which contained 1% cholesterol plus 10%
saturated animal fat added to the normal rat diet), groups 3 and 4
were fed hypercholesterolemic diet in addition to Citrus reticulata
ethanolic extract at doses of (250mg/kg (group 3) and 500mg/kg
(group 4)) administered daily via oral route, groups 5 and 6 were
given hypercholesterolemic diet in addition to Zingiber officinale
ethanolic extract at doses of (250mg/kg (group 5) and 500mg/kg
(group 6)) daily through oral route, groups 7 and 8 fed on
hypercholesterolemic diet in addition to Sesamum indicum ethanolic
extract at doses of (250mg/kg (group 7) and 500mg/kg (group 8))
daily orally; and group 9 rats were given hypercholesterolemic diet in
addition to atorvastatin (0.18mg/kg) daily via oral route as a standard
reference antihypercholesterolemic drug. Blood samples from all
groups were drawn from the retro-orbital venous plexus four weeks
following treatment after overnight fasting and the lipid profile (total
cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low
density lipoprotein-cholesterol (LDL-C) and triglyceride levels) were
measured and the risk ratio (TC/HDL-C) was assessed. The
antioxidant activity of the three plants extracts was determined using
DPPH free-radical antioxidant assay. Results of in vivo and in vitro
antihypercholesterolemic and antioxidant assay respectively, revealed
that the three extracts possess comparable antioxidant and
antihypercholesterolemic activities.},
    journal   = {International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering},  volume    = {9},
  number    = {12},
  year      = {2015},
  pages     = {801 - 808},
  ee        = {http://waset.org/publications/10002875},
  url       = {http://waset.org/Publications?p=108},
  bibsource = {http://waset.org/Publications},
  issn      = {eISSN:1307-6892},
  publisher = {World Academy of Science, Engineering and Technology},
  index     = {International Science Index 108, 2015},
}