Open Science Research Excellence
%0 Journal Article
%A M. Mousavi-Daramoroudi and  H. Yousefnia and  F. Abbasi-Davani and  S. Zolghadri
%D 2018 
%J  International Journal of Pharmacological and Pharmaceutical Sciences
%B World Academy of Science, Engineering and Technology
%I International Science Index 138, 2018
%T Time Dependent Biodistribution Modeling of  177Lu-DOTATOC Using Compartmental Analysis
%U http://waset.org/publications/10009337
%V 138
%X In this study, 177Lu-DOTATOC was prepared under optimized conditions (radiochemical purity: > 99%, radionuclidic purity: > 99%). The percentage of injected dose per gram (%ID/g) was calculated for organs up to 168 h post injection. Compartmental model was applied to mathematical description of the drug behaviour in tissue at different times. The biodistribution data showed the significant excretion of the radioactivity from the kidneys. The adrenal and pancreas, as major expression sites for somatostatin receptor (SSTR), had significant uptake. A pharmacokinetic model of 177Lu-DOTATOC was presented by compartmental analysis which demonstrates the behavior of the complex.
%P 292 - 295