Open Science Research Excellence
%0 Journal Article
%A Weronika Kurowska-Nouyrigat and  Jacek Szumbarski
%D 2009 
%J  International Journal of Medical, Health, Biomedical, Bioengineering and Pharmaceutical Engineering
%B World Academy of Science, Engineering and Technology
%I International Science Index 34, 2009
%T Numerical Simulation of Restenosis in a Stented Coronary Artery
%U http://waset.org/publications/10419
%V 34
%X Nowadays, cardiac disease is one of the most common
cause of death. Each year almost one million of angioplasty interventions and stents implantations are made all over the world.
Unfortunately, in 20-30% of cases neointimal proliferations leads to
restenosis occurring within the following period of 3-6 months. Three major factors are believed to contribute mostly to the edge
restenosis: (a) mechanical damage of the artery-s wall caused by the
stent implantation, (b) interaction between the stent and the blood constituents and (c) endothelial growth stimulation by small (lower
that 1.5 Pa) and oscillating wall shear stress. Assuming that this last actor is particularly important, a numerical model of restenosis
basing on wall shear stress distribution in the stented artery was elaborated. A numerical simulations of the development of in-stent
restenosis have been performed and realistic geometric patterns of a
progressing lumen reduction have been obtained
%P 268 - 272