Open Science Research Excellence
%0 Journal Article
%A N. Tuncbag and  T. Haliloglu and  O. Keskin
%D 2008 
%J  International Journal of Chemical, Molecular, Nuclear, Materials and Metallurgical Engineering
%B World Academy of Science, Engineering and Technology
%I International Science Index 20, 2008
%T Observation of the Correlations between Pair Wise Interaction and Functional Organization of the Proteins, in the Protein Interaction Network of Saccaromyces Cerevisiae
%U http://waset.org/publications/4812
%V 20
%X Understanding the cell's large-scale organization is an
interesting task in computational biology. Thus, protein-protein
interactions can reveal important organization and function of the
cell. Here, we investigated the correspondence between protein
interactions and function for the yeast. We obtained the correlations
among the set of proteins. Then these correlations are clustered using
both the hierarchical and biclustering methods. The detailed analyses
of proteins in each cluster were carried out by making use of their
functional annotations. As a result, we found that some functional
classes appear together in almost all biclusters. On the other hand, in
hierarchical clustering, the dominancy of one functional class is
observed. In brief, from interaction data to function, some correlated
results are noticed about the relationship between interaction and
function which might give clues about the organization of the
proteins.
%P 187 - 192