The present study is a foundational study for performance improvements on isolation wards to prevent proliferation of secondary infection of infectious diseases such as SARS, H1N1, and MERS inside hospitals. Accordingly, the present study conducted an analysis of the effect of sealing mechanisms and filling of openings on ensuring air tightness performance in isolation wards as well as simulation on air currents in improved isolation wards. The study method is as follows. First, previous studies on aerial infection type and mechanism were reviewed, and the review results were utilized as basic data of analysis on simulation of air current. Second, national and international legislations and regulations in relation to isolation wards as well as case studies on developed nations were investigated in order to identify the problems in isolation wards in Korea and improvement plans. Third, construction and facility plans were compared and analyzed between general and isolation wards focusing on large general hospitals in Korea, thereby conducting comparison and analysis on the performance and effects of air-tightness of general and isolation wards through CFD simulations. The study results showed that isolation wards had better air-tightness performance than that of general wards.
 Bang, J. (2016). Study on air migration in negative pressure isolation room during door openings and human movement, Architectural Institute of Korea Annual Conference 2016.04, 265-266.
 G. Cao1, P. V. Nielsen, R. L. Jensen2, P. Heiselberg, L. Liu, J. Heikkinen (2015) Protected zone ventilation and reduced personal exposure to airborne cross-infection, Indoor Air 2015; 25: 307–319.
 Catherine, J., & P, Andrew Sleigh. (2008). Applying the Wells-Riley equation to the risk of airborne infection in hospital environments: The importance of stochastic and proximity effects, Indoor Air, 17-22.
 Centers for disease control & prevention, (2014). Guidelines for Environmental Infection Control in Healthcare Facilities.
 Centers for diease control & prevention, (2015). Infection diseases surveillance yearbook.
 Contemporary Architecture Committee of terms Compilation, (2011). A glossary of architectural terms.
 Doopedia, Aerial(Airborne) infection. 2016.
 Jo, Seong-Min., Sung, Min-Ki., Kwon, Soon-Jung. (2014) A Study on the Movement of Air in the Negative Pressure Isolation Facility, Arechtectural institute of korea, 2014.4, 269-270.
 Jun-Han Youn, Hyoung-Jae Jin, Chan-Seok Park, Dae-In Kim, Jong-Sun Cho. (2013) Design and procedures of air conditioning system in the Passive House, The Society of Air-conditioning and refrigerating engineers of korea 2013.6, 673-676.
 Lee, S. (2015). A case study and response plan in design for prevention of secondary infection in hospital, The magazine of the Society of Air-Conditioning and Refrigerating Engineers of Korea 44(8). 68-75.
 Lim, T. (2009). A Inquiry of Tracer Gas for Analysis of Daspersion and Prediction of Infection Possibillity according to Airborne Viral Contaminants, Jounal of the Korean Institute of Interior Design 18(3).
 Ministry of Health and Welfare of Korea. (2011). Operation and management of Government designated hospital treatment (isolation) beds (Plan).
 Ministry of health and welfare of Korea. (2015) Hospital which MERS patients were founded 2015.
 M. Sung, “Hospital’s air conditioning and control of infection through MERS,” The magazine of the society of air-conditioning and refrigerating engineers of Korea, vol. 44, no. 8, pp.58-64, 2015.
 Presidential Commission on Architecture Policy. (2016). A study on the formation of safety and healthy indoor environment by improvement of indoor air quality of medical and multi-use facilities.
 SAREK, Determination of the separation between rooms, ward rooms, hospital beds, and separation of beds and beds in hospital rooms. Presidential commission on architecture policy. 2016.
 S. Lee, “Prevented technique for infection at hospital,” The magazine of the society of air-conditioning and refrigerating engineers of Korea vol. 44, no. 3, pp.64-75, 2015.
 WHO, (2007). Wells-Reiley equation.