Effect of oral administration of “Gadagi" tea on liver
function was assessed on 50 healthy male albino rats which were
grouped and administered with different doses(mg/kg) i.e low dose
(380mg/kg, 415mg/kg, 365mg/kg, 315mg/kg for “sak", “sada" and
“magani" respectively), standard dose ( 760mg/kg, 830mg/kg,
730mg/kg for “sak-, “sada" and “magani" respectively) and high dose
(1500mg/kg, 1700mg/kg and 1460mg/kg for “sak--,"sada" and
“magani" groups respectively) for a period of four weeks. Animals
that were not administered with the tea constituted the control group.
At the end of fourth week, the animals were sacrificed and their
serum alanine aminotransferase (ALT), aspartate aminotransferase
(AST), alkaline phosphatase (ALP), total protein (TP), albumin
(ALB), and globulins (GLO) were determined. Mean serum ALT and
ALP activities were significantly higher (P<0.05) in rats orally
administered with high dose of “sak" and those administered with
standard dose of “sada" than those of the control group, suggesting a
probable impairment of liver function due to liver cytolysis.Mean
serum AST, ALT and ALP activities were significantly lower
(P<0.05) in rats that were orally administered with high dose of
“magani" than that of the control group, suggesting a probable
improvement in liver function (due to decrease in liver cytolysis).
Mean serum TP, ALB and GLO levels were significantly higher
(P<0.05) in rats that were orally administered with the various doses
of“sak", “sada" and “magani" than those of the control group. This
also suggests a probable improvement in the synthetic function of the
liver.Thus, some dosages of “sak" and “sada could be hepatotoxic,
whereas “magani" especially at the high dose administered could
have pharmacologically positive effect on the liver of the rats.
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