Excellence in Research and Innovation for Humanity

International Science Index

Select areas to restrict search in scientific publication database:
ICAM-2, A Protein of Antitumor Immune Response in Mekong Giant Catfish (Pangasianodon gigas)
ICAM-2 (intercellular adhesion molecule 2) or CD102 (Cluster of Differentiation 102) is type I transmembrane glycoproteins, composing 2-9 immunoglobulin-like C2-type domains. ICAM-2 plays the particular role in immune response and cell surveillance. It is concerned in innate and specific immunity, cell survival signal, apoptosis, and anticancer. EST clone of ICAM-2, from P. gigas blood cell EST libraries, showed high identity to human ICAM-2 (92%) with conserve region of ICAM N-terminal domain and part of Ig superfamily. Gene and protein of ICAM-2 has been founded in mammals. This is the first report of ICAM-2 in fish
Digital Article Identifier (DAI):


[1] K. Ley, C. Laudanna, M.I. Cybulsky and S. Nourshargh. "Getting to the site of inflammation: the leukocyte adhesion cascade updated.” Nature Reviews Immunology, vol. 7, pp. 678-689, September 2007.
[2] D. E.Staunton, M. L. Dustin and T.A. Springer. "Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1.” Nature, pp. 339: 61-64. 1989.
[3] A. R.de Fougerolles, S. A. Stacker, R. Schwarting and T. A. Springer "Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1.” Journal of Experiment Medicine, vol. 174, pp. 253-267, 1991.
[4] T. G. Diacovo, A. R.de Fougerolles, D. F. Bainton and T. A. Springer. "A functional integrin ligand on the surface of platelets: inter-cellular adhesion molecule-2.” Journal of Clinical Investigation, vol. 94, pp.1243-1251, 1994.
[5] N. Gerwin, J. A. Gonzalo, C. Lloyd, A. J. Coyle, Y. Reiss, N. Banu, B. Wang, H. Xu, H. Avraham, B. Engelhardt, T. A. Springer, J. C. Gutierrez-Ramos. "Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2 deficient mice results in extended hyper-responsiveness.” Immunity, vol.10, pp. 9-19, 1999.
[6] J. T. Pai and E. Ruoslahta. "Identification of endothelial genes up-regulated in vivo.” Gene, vol.347, pp. 21-33, 2005.
[7] O. D. Perez, S. Kinoshita, Y. Hitoshi, D. G. Payan, T. Kitamura, G. P. Nolan and J. B. Lorens. "Activation of the PKB/AKT pathway by ICAM-2.” Immunity, vol. 16 issue 1, pp. 51-65, 2002.
[8] L. Zhiyong, G. Ben and D.L. Richard. "Expression of intercellular adhesion molecule (ICAM)-1 or ICAM-2 is critical in determining sensitivity of pancreatic cancer cells to cytolysis by human (gamma)(delta)-T cells: Implications in the design of (gamma)(delta)-T-cell-based immunotherapies for pancreatic cancer.” Journal of Gastroenterology & Hepatology, vol. 24 issue 5, pp. 900-911, 2009.
[9] N. Hiraoka, R. Yamazaki-Itoh, Y. Ino, Y. Mizuguchi, T. Yamada, S. Hirohashi and Y. Kanai. "CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis.” Gastroenterology, vol. 140, pp. 310-321, 2011.
[10] I. Melero, I. Gabari, A. L. Corbı´, M. Relloso, G. Mazzolini, V. Schmitz, M. Rodriguez-Calvillo, I. Tirapu, E. Camafeita, J. P. Albar, and J. Prieto. "An Anti-ICAM-2 (CD102) Monoclonal Antibody Induces Immune-mediated Regressions of Transplanted ICAM-2-negative Colon Carcinomas.” Cancer Research, vol. 62, pp. 3167–3174, June 1, 2002.
[11] P. Galea, C. Vermot-Desroches, C. Le Contel, J. Wijdenes and J. C. Chermann. "Circulating cell adhesion molecules in HIV1-infected patients as indicator markers for AIDS progression.” Research Immunology, vol. 148, pp. 109-117, 1997.
[12] K. J. Yoon, D. A. Phelps, R. A. Bush, J. S. Remack, C. A. Billups and J. D. Khoury. "ICAM-2 Expression Mediates a Membrane-Actin Link, Confers a Nonmetastatic Phenotype and Reflects Favorable Tumor Stage or Histology in Neuroblastoma.” PLoS ONE, vol. 3 issue 11, e3629 November 2008.
[13] H. Tanaka, M. Yashiro, T. Sunami, Y. Sakate, K. Kosaka, and K. Hirakawa. "ICAM-2 Gene Therapy for Peritoneal Dissemination of Scirrhous Gastric Carcinoma.” Clinical Cancer Research, vol. 10, pp. 4885–4892, July 15, 2004.
[14] K. J. Yoon and M. K. Danks. "Review : Cell adhesion molecules as targets for therapy of neuroblastoma.” Cancer Biology & Therapy, vol. 8 issue 4, pp. 306-311, 15 February 2009.
[15] J. Sambrook, E.F. Frisch, and, T. Maniatis, "Molecular Cloning, A Laboratory Manual”, Cold Spring Harbor: Cold Spring Harbor Laboratory Press.,1989.
[16] A. R. de Fougerolles, S. A. Stacker, R. Schwarting and T. A. Springer. "Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1.” Journal of Experimental Medicine, vol. 174, pp. 253-267, July 1991.
[17] H. Xu, J. K. Bickford, E. Luther, C. Carpenito, F. Takei, T.A. Springer. "Characterization of murine intercellular adhesion molecule-2.” Journal of Immunology, vol. 156 issue 12, pp. 4909-4914. June 15, 1996.
[18] J. M. Casasnovas, T. A. Springer, J. H. Liu, S. C. Harrison and J. H. Wang. "Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface.” Nature, vol. 387 issue 6630, pp. 312-315, May 15, 1997.
[19] J. W. Godwina, A. J. F. d’Apicea and P. J. Cowana. "Characterization of Pig Intercellular Adhesion Molecule-2 and its Interaction with Human LFA-1.” American Journal of Transplantation, vol. 4, pp. 515–525, 2004.
Vol:12 No:09 2018Vol:12 No:08 2018Vol:12 No:07 2018Vol:12 No:06 2018Vol:12 No:05 2018Vol:12 No:04 2018Vol:12 No:03 2018Vol:12 No:02 2018Vol:12 No:01 2018
Vol:11 No:12 2017Vol:11 No:11 2017Vol:11 No:10 2017Vol:11 No:09 2017Vol:11 No:08 2017Vol:11 No:07 2017Vol:11 No:06 2017Vol:11 No:05 2017Vol:11 No:04 2017Vol:11 No:03 2017Vol:11 No:02 2017Vol:11 No:01 2017
Vol:10 No:12 2016Vol:10 No:11 2016Vol:10 No:10 2016Vol:10 No:09 2016Vol:10 No:08 2016Vol:10 No:07 2016Vol:10 No:06 2016Vol:10 No:05 2016Vol:10 No:04 2016Vol:10 No:03 2016Vol:10 No:02 2016Vol:10 No:01 2016
Vol:9 No:12 2015Vol:9 No:11 2015Vol:9 No:10 2015Vol:9 No:09 2015Vol:9 No:08 2015Vol:9 No:07 2015Vol:9 No:06 2015Vol:9 No:05 2015Vol:9 No:04 2015Vol:9 No:03 2015Vol:9 No:02 2015Vol:9 No:01 2015
Vol:8 No:12 2014Vol:8 No:11 2014Vol:8 No:10 2014Vol:8 No:09 2014Vol:8 No:08 2014Vol:8 No:07 2014Vol:8 No:06 2014Vol:8 No:05 2014Vol:8 No:04 2014Vol:8 No:03 2014Vol:8 No:02 2014Vol:8 No:01 2014
Vol:7 No:12 2013Vol:7 No:11 2013Vol:7 No:10 2013Vol:7 No:09 2013Vol:7 No:08 2013Vol:7 No:07 2013Vol:7 No:06 2013Vol:7 No:05 2013Vol:7 No:04 2013Vol:7 No:03 2013Vol:7 No:02 2013Vol:7 No:01 2013
Vol:6 No:12 2012Vol:6 No:11 2012Vol:6 No:10 2012Vol:6 No:09 2012Vol:6 No:08 2012Vol:6 No:07 2012Vol:6 No:06 2012Vol:6 No:05 2012Vol:6 No:04 2012Vol:6 No:03 2012Vol:6 No:02 2012Vol:6 No:01 2012
Vol:5 No:12 2011Vol:5 No:11 2011Vol:5 No:10 2011Vol:5 No:09 2011Vol:5 No:08 2011Vol:5 No:07 2011Vol:5 No:06 2011Vol:5 No:05 2011Vol:5 No:04 2011Vol:5 No:03 2011Vol:5 No:02 2011Vol:5 No:01 2011
Vol:4 No:12 2010Vol:4 No:11 2010Vol:4 No:10 2010Vol:4 No:09 2010Vol:4 No:08 2010Vol:4 No:07 2010Vol:4 No:06 2010Vol:4 No:05 2010Vol:4 No:04 2010Vol:4 No:03 2010Vol:4 No:02 2010Vol:4 No:01 2010
Vol:3 No:12 2009Vol:3 No:11 2009Vol:3 No:10 2009Vol:3 No:09 2009Vol:3 No:08 2009Vol:3 No:07 2009Vol:3 No:06 2009Vol:3 No:05 2009Vol:3 No:04 2009Vol:3 No:03 2009Vol:3 No:02 2009Vol:3 No:01 2009
Vol:2 No:12 2008Vol:2 No:11 2008Vol:2 No:10 2008Vol:2 No:09 2008Vol:2 No:08 2008Vol:2 No:07 2008Vol:2 No:06 2008Vol:2 No:05 2008Vol:2 No:04 2008Vol:2 No:03 2008Vol:2 No:02 2008Vol:2 No:01 2008
Vol:1 No:12 2007Vol:1 No:11 2007Vol:1 No:10 2007Vol:1 No:09 2007Vol:1 No:08 2007Vol:1 No:07 2007Vol:1 No:06 2007Vol:1 No:05 2007Vol:1 No:04 2007Vol:1 No:03 2007Vol:1 No:02 2007Vol:1 No:01 2007