Excellence in Research and Innovation for Humanity

International Science Index

Select areas to restrict search in scientific publication database:
Mucosal- Submucosal Changes in Rabbit Duodenum during Development
The sequential morphologic changes of rabbit duodenal mucosa-submucosa were studied from primodial stage to birth in 15 fetuses and during the early days of life in 21 rabbit newborns till maturity using light, scanning and transmission electron microscopy. Fetal rabbit duodenum develops from a simple tube of stratified epithelium to a tube containing villus and intervillus regions of simple columnar epithelium. By day 21 of gestation, the first rudimentary villi were appeared and by day 24 the first true villi were appeared. The Crypts of Lieberkuhn did not appear until birth. By the first day of postnatal life the duodenal glands appeared. The histological maturity of the rabbit small intestine occurred one month after birth. In conclusion, at all stages, the sequential morphologic changes of the rabbit small intestine developed to meet the structural and physiological demands during the fetal stage to be prepared to extra uterine life.
Digital Article Identifier (DAI):


[1] Trier.; Jerry, S. and Moxey Pamela Colony (1979): Morphogenesis of the Small Intestine during Fetal Development. Ciba Foundation Symposium 70 - Development of Mammalian Absorptive Processes. Chapter 2, 3-29.
[2] Sunshine, P.; Herbest, J.J. and Koldovsky, O. et al. (1971): Adaptation of the gastrointestinal tract to extrauterine life. Ann NY Acad Sci 176:16-29.
[3] Deren, J.J.; Strauss, E.W., Wilson, T.H. (1965): The development of structure and transport systems of the fetal rabbit intestine. Dev Biol 12:467-486.
[4] Toofanian, F.; Hill, F.W.G. and Kidder, D.E. (1974): The development of the intestine disaccharidase activities in the fetal and newborn calf. Res Vet Sci 16:375-381.
[5] Cunningham, J. G. & B. G. Klein, 2007. Textbook of Veterinary Physiology, 4th edn, Elsevier Health Sciences
[6] Crescenzi, A., Barsotti, P., Anemona, L. and Marinozzi, V. (1988): Carbohydrate histochemistry of human Brunner's glands. Histochem., 90:47-49.
[7] Krause, W. J. (2000): Brunner's glands: A structural, histochemical and pathological profile. Progr. Histochm Cytochem, 35:255-367.
[8] Takehana, K., Abe, M., Iwasa, K. and Hiraga, T. (1989): Histochemistry of complex carbohydrates in the horse duodenal gland. Jap. J. Vet. Sci., 51:909-916.
[9] Takehana, K., Masty, J., Abe, M. and Yamaguchi, M. (1991 a): Duodenal glands of the pony. (Equus caballus). Anat. Hostol. Embryol, 20:1-9.
[10] Takehana, K. Ueda Eerdunchaoluo, H., Kobayashi, A., Iwasa, K. and Sou, K. (2000): A histichemical study of the camel (Camelus bactrianus) duodenal glands. J. Vet. Med. Sci., 62:449-452.
[11] Verdiglione, R., Mammola, C.L. and Filotto, U. (2002): Glycoconjugate histochemistry of bovine Brunner's glands. Ann. Anat., 184:61-69.
[12] Bancroft, J.D. and Gamble, M. (2008): Theory and practice of histological techniques. Sixth edition.
[13] McDowell, E. and Trump, B. (1976): Histological fixatives for diagnostic light and electron microscopy. Arch. Pathol. Lab. Med. 100:405-414.
[14] Hayat, M., (1986): Basic Techniques for transmission electron microscopy. 2nd Ed, Academic Press, Baltimore.
[15] O'Connor, T.M. (1966): Cell dynamics in the intestine of the mouse from late fetal life to maturity. Am. J. Anat., 118:525-536.
[16] Lev, R., Siegel, H.I. and Bartman, J. (1972): Histochemical studies of developing human fetal small intestine. Histochem.,29:103-119.
[17] Toofanian, F. (1976a): Histological observations on the developing intestine of the bovine fetus. Res. Vet. Sci., 21:36-40.
[18] Toofanian, F. (1976b): Histological development of the small intestinal mucosa in the ovine fetus. Res. Vet. Sci., 21:349-353
[19] Toofanian, F. and Targowski, S. P. (1982): Morphogenesis of rabbit small intestinal mucosa. Am. J. Vet. Res., 43:2213-2217.
[20] Sbarbati, R. (1982): Morphogenesis of the intestinal villi of the mouse embryo: chance and spatial necessity. J. Anat. 135:477-499.
[21] Hilton, W. A. (1902): The morphology and development of intestinal folds and villi in vertebrates. Am. J. Anat . 1:459-504.
[22] Kammeraad, A. (1942): The development of the gastro-intestinal tract of the rat. I. Histogenesis of the epithelium of the stomach, small intestine and paancreas. J. Morphol.,70: 323-352.
[23] Coulombre, A.J. and Coulombre, J.L. (1958): Intestinal development. I. Morphogenesis of the villi and musculature. J. Embryol. Exp. Morphol. 6:403-411.
[24] Burgess, D. (1975): Morphogenesis of intestinal villi. Mechanism of formation of previllous ridges. J. Embryol. Exp. Morphol., 34:723-740.
[25] Grey. and Robert, D. (1972): Morphogenesis of intestinal villi. I. Scanning electron microscopy of the duodenal epithelium of the developing chick embryo. J. Morph, 137, 193-213.
[26] Deren, J.J. (1968): Development of intestinal structure and function, in Code CF(ed): Handbook of physiology. Washington DC, American Physiological Society., 1099-1123.
[27] Krause, W. J. and Leeson, C. R. (1967): The origin, development and differentiation of Brunner's glands in the rat. J. Anat., 101:309-320.
[28] Tsai, L. J. and Overton, J. (1976): The relation between villus formation and the pattern of extracellular fibers as seen by scanning microscopy. Dev. Biol., 52:61-73.
[29] Nakamura, K. and Komuro, T. (1983): A three-dimentional study of the embryonic development and postnatal maturation of rat duodenal villi. J. Electron. Microsc, 32:338-347.
[30] Mellor, D.J., Xu, R.J., Tungthanathanich, P., Birtles, M.J., Reynolds, G.W. and Simpson, H.V. (1992): Growth and morphological changes in the small intestine in piglets during the first three days after birth. J. Dev. Physiol. 18: 161-172.
[31] Marion, J., Rome', V., Savary, G., Thomas, F., Le Dividich, J. and Le Huerou-Luron, I. (2003): Weaning and feed intake alter pancreatic enzyme activities and corresponding mRNA Levels in 7-d-old piglets. J. Nutr., 133: 362-368.
[32] Leblond, C. P. and Messier, B. (1958): Renewal of chief cells and goblet cells in the small intestine as shown by radioautography after injection of thymidin-H3 into mice. Anat. Rec.132:247-259.]
[33] Creamer, B., Shorter, R. G. and Bamforth, J. (1961a): The turenover and shedding of epithelial cells. I. The turnover in the gastrointestinal tract. Gut 2:110-116.
[34] Creamer, B., Shorter, R. G. and Bamforth, J. (1961b): The turenover and shedding of epithelial cells. II. The shedding in the small intestine. Gut 2: 117-118.
[35] Cheng, H. and Leblond, C. P. (1974): Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell. III. Enteroendocrine cells. Amer. J. Anat., 141:461-480, 503-520.
[36] Johnson, F. P. (1910): The development of the mucous membrane of esophagus, stomach, and small intestine in the human embryo. Am. J. Anat., 10:521-56.
[37] Spicer, S.S. and Schulte, B.A. (1992): Diversity of cell glycoconjugates shown histochemically: a percpective. J Histochem Cytochem 40: 1-38.
[38] Ergun, E., Ergun, L., Ozen, A., Kurum, A. and Bayrakataroglu, A.G. (2010): Histomorphology of the Brunner's glands in the Angora rabbit. J Anim Vet.9:887-891.
[39] Colony, P.C. and Specian, R.D. (1987): Endocytosis and vesicular traffic in fetal and adult colonic goblet cells. Anat. Rec., 218, 365-372.
[40] Troughton, W. D. and J. S. Trier (1969): Paneth and Goblet cell renewal in mouse duodenal crypts. J. Cell. Biol., 41: 251-268.
[41] Kataoka, K. (1970): The fine structure of the proliferative cells of the mouse intestine as revealed by electron microscopic autoradiography with 3H-thymidine. Z. Zellforsch.103: 170-178.
[42] Kurosumi, K., Shibuichi, I. and Tosaka, H. (1981): Transition between columnar absorptive cells andgoblet cells in the rat jejunal epithelium. Arch. histol. jap., 44: 405-427.
[43] Brown, W. R., Isobe, Y. and Nakane, P. K. (1976): Studies on translocation of immunoglobulins across intestinal epithelium. II. Immunoelectron-microscopic localization of immunoglobulins and secretory component in human intestinal mucosa. Gastroenterol., 71: 985-995.
[44] Bonneville, M. A. and Weinstock, M. (1970): Brush border development in the intestinal absorptive cells of Xenopus during metamorphosis. J. Cell. Biol., 44:151-171.
[45] Laster, L. and Ingelfinger, F. J. (1961): Intestinal absorption--aspects of structure, function and disease of the small-intestine mucosa. N. Engl. J. Med. 1; 264-1138.
[46] Padykula, H. A. (1962): Recent functional interpretations of intestinal morphology. Federation Proceedings 21, 873-879.
[47] Takehana, K., Abe, M., Iwasa, K., Hiraga, T. and Miyata, H. (1991b): Carbohydrate histochemistry of bovine duodenal glands. J. Vet. Med. Sci., 53:699-706.
[48] Friend, D. S. (1965): The fine structure of Brunner's glands in the mouse. J. Cell. Biol., 25, 563-576.
[49] Moe, H. (1960): The ultrastructure of Brunner-s glands of the cat. J. Ultrastruct. Res., 4: 58-72.
[50] Odduor-Okelo, D. (1976): Histochemistry of the duodenal glands of cat and horse. Acta. Anat., 94:449-456.
[51] Pfeiffer, C. J. and Dabareiner, R. M. (1992): Ultrastructure of Brunner's glands in the horse. J. Submicrosc Cytol. Pathol., 24:581-588.
[52] Cochrane, W., Davies, D. V. Palfrey, A. J. and Stockwell, R. A. (1964): The histochemistry and electronniicroscopy of Brunner-s glands in the guinea-pig. J. Anat., 98: 1-10.
[53] Krause, W. J. (1981): Morphological and histochemical observations on the duodenal glands of eight wild ungulate species native to North America. Am. J. Anat., 162:167-181.
[54] Leeson, C. R. and Leeson, T. S. (1967): The fine structure of Brunner's glands in the rabbit. Anatomical Record 159, 409-420.
Vol:12 No:05 2018Vol:12 No:04 2018Vol:12 No:03 2018Vol:12 No:02 2018Vol:12 No:01 2018
Vol:11 No:12 2017Vol:11 No:11 2017Vol:11 No:10 2017Vol:11 No:09 2017Vol:11 No:08 2017Vol:11 No:07 2017Vol:11 No:06 2017Vol:11 No:05 2017Vol:11 No:04 2017Vol:11 No:03 2017Vol:11 No:02 2017Vol:11 No:01 2017
Vol:10 No:12 2016Vol:10 No:11 2016Vol:10 No:10 2016Vol:10 No:09 2016Vol:10 No:08 2016Vol:10 No:07 2016Vol:10 No:06 2016Vol:10 No:05 2016Vol:10 No:04 2016Vol:10 No:03 2016Vol:10 No:02 2016Vol:10 No:01 2016
Vol:9 No:12 2015Vol:9 No:11 2015Vol:9 No:10 2015Vol:9 No:09 2015Vol:9 No:08 2015Vol:9 No:07 2015Vol:9 No:06 2015Vol:9 No:05 2015Vol:9 No:04 2015Vol:9 No:03 2015Vol:9 No:02 2015Vol:9 No:01 2015
Vol:8 No:12 2014Vol:8 No:11 2014Vol:8 No:10 2014Vol:8 No:09 2014Vol:8 No:08 2014Vol:8 No:07 2014Vol:8 No:06 2014Vol:8 No:05 2014Vol:8 No:04 2014Vol:8 No:03 2014Vol:8 No:02 2014Vol:8 No:01 2014
Vol:7 No:12 2013Vol:7 No:11 2013Vol:7 No:10 2013Vol:7 No:09 2013Vol:7 No:08 2013Vol:7 No:07 2013Vol:7 No:06 2013Vol:7 No:05 2013Vol:7 No:04 2013Vol:7 No:03 2013Vol:7 No:02 2013Vol:7 No:01 2013
Vol:6 No:12 2012Vol:6 No:11 2012Vol:6 No:10 2012Vol:6 No:09 2012Vol:6 No:08 2012Vol:6 No:07 2012Vol:6 No:06 2012Vol:6 No:05 2012Vol:6 No:04 2012Vol:6 No:03 2012Vol:6 No:02 2012Vol:6 No:01 2012
Vol:5 No:12 2011Vol:5 No:11 2011Vol:5 No:10 2011Vol:5 No:09 2011Vol:5 No:08 2011Vol:5 No:07 2011Vol:5 No:06 2011Vol:5 No:05 2011Vol:5 No:04 2011Vol:5 No:03 2011Vol:5 No:02 2011Vol:5 No:01 2011
Vol:4 No:12 2010Vol:4 No:11 2010Vol:4 No:10 2010Vol:4 No:09 2010Vol:4 No:08 2010Vol:4 No:07 2010Vol:4 No:06 2010Vol:4 No:05 2010Vol:4 No:04 2010Vol:4 No:03 2010Vol:4 No:02 2010Vol:4 No:01 2010
Vol:3 No:12 2009Vol:3 No:11 2009Vol:3 No:10 2009Vol:3 No:09 2009Vol:3 No:08 2009Vol:3 No:07 2009Vol:3 No:06 2009Vol:3 No:05 2009Vol:3 No:04 2009Vol:3 No:03 2009Vol:3 No:02 2009Vol:3 No:01 2009
Vol:2 No:12 2008Vol:2 No:11 2008Vol:2 No:10 2008Vol:2 No:09 2008Vol:2 No:08 2008Vol:2 No:07 2008Vol:2 No:06 2008Vol:2 No:05 2008Vol:2 No:04 2008Vol:2 No:03 2008Vol:2 No:02 2008Vol:2 No:01 2008
Vol:1 No:12 2007Vol:1 No:11 2007Vol:1 No:10 2007Vol:1 No:09 2007Vol:1 No:08 2007Vol:1 No:07 2007Vol:1 No:06 2007Vol:1 No:05 2007Vol:1 No:04 2007Vol:1 No:03 2007Vol:1 No:02 2007Vol:1 No:01 2007