MITOS-RCNN: Mitotic Figure Detection in Breast Cancer Histopathology Images Using Region Based Convolutional Neural Networks
Studies estimate that there will be 266,120 new cases
of invasive breast cancer and 40,920 breast cancer induced deaths
in the year of 2018 alone. Despite the pervasiveness of this
affliction, the current process to obtain an accurate breast cancer
prognosis is tedious and time consuming. It usually requires a
trained pathologist to manually examine histopathological images and
identify the features that characterize various cancer severity levels.
We propose MITOS-RCNN: a region based convolutional neural
network (RCNN) geared for small object detection to accurately
grade one of the three factors that characterize tumor belligerence
described by the Nottingham Grading System: mitotic count. Other
computational approaches to mitotic figure counting and detection
do not demonstrate ample recall or precision to be clinically viable.
Our models outperformed all previous participants in the ICPR 2012
challenge, the AMIDA 2013 challenge and the MITOS-ATYPIA-14
challenge along with recently published works. Our model achieved
an F- measure score of 0.955, a 6.11% improvement in accuracy from
the most accurate of the previously proposed models.
Object detection, histopathology, breast cancer, mitotic
count, deep learning, computer vision.