B. Zygmunt and M. Veldhoen, "T helper cell differentiation more than
just cytokines", Adv. Immunol., 109:159-196, 2011.
 T.T. Mossman and S. Sad, "The expanding universe of T-cell subsets:
Th1, Th2 and more", Immunol. Today, 17:138-146, 1996.
 D.A. Mata-Espinosa and R. Hern├índez-Pando, "Gamma interferon:
basics aspects, clinic significance and terapeutic uses", Rev. Invest.
Clin., 60:421-431, 2008.
 D. Amsen, C.G. Spilianakis and R.A. Flavell, "How are T(H)1 and
T(H)2 effector cells made?", Curr. Opin. Immunol., 21:153-160, 2009.
 J.C.S. Bergh, T.H. Tötterman, B.C. Termander, K.A. Strandg├Ñrden,
P.O.G. Gunnarsson and B.I. Nilsson, "The first clinical pilot study of
roquinimex (Linomide) in cancer patients with special focus on
immunological effects", Cancer Invest., 15:204-211, 1997.
 J.B. Calixto, M.M. Campos, M.F. Otuki and A.R.S. Santos ARS,
"Anti-inflammatory compounds of plants origin, modulation of
proinflammatory cytokines, chemokines and adhesion molecules" ,
Planta Med., 70:93-103, 2004.
 G. Hedlund, H. Link, J. Zhu and B.G. Xiao, "Effects of Linomide on
immune cells and cytokines inhibit autoimmune pathologies of the
central and peripheral nervous system", Int. Immunopharmacol.,
 A.M. Thompson, G.W. Rewcastle, S.L. Boushelle, B.G. Hartl, A.J.
Kraker, G.H. Lu, B.L. Batley, R.L. Panek, H.D. Showalter and W.A.
Denny, "Synthesis and structure-activity relationships of 7-substituted
3-(2, 6-dichlorophenyl)-1,6-naphthyridin-2(1H)-ones as selective
inhibitors of pp60(c-src)", J. Med. Chem., 43:3134-3147, 2000.
 P. Traxler P, "Tyrosine kinases as targets in cancer therapy - successes
and failures", Expert Opin. Ther. Targets, 7:215-234, 2003.
 Y. Baba Hamed, A. Medjdoub, B. Mostefa Kara, H. Merzouk, D.
Villemin and M. Narce, "5,6-Dihydro-2H-pyranones and 5,6-dihydro-
2H-pyridones and their derivatives modulate in vitro human T
lymphocyte function", Mol. Cell. Biochem., 360:23-33, 2012.
 D. Jansone, S. Belyakov, M. Fleisher, L. Leite and E. Lukevics,
"Molecular and crystal structure of 4,6,6-trimethyl- 2-oxo-5,6-dihydro-
2h-pyran- 3-carbonitrile and 4,6,6-trimethyl- 2-oxo-1,2,5,6
tetrahydropyridine- 3-carbonitrile", Chem. Heterocycl. Comp.,
 E. Lukevic, D. Jansone, E. Leite, J. Popelis, G. Andreeva, L.
Shestakova, I. Domracheva, V. Bridane and I. Kanepe, "Synthesis and
cytotoxicity of phenyl- vinyl derivatives of 4,6,6-trimethyl-2-oxo-
1,2,5,6-tetrahydropyridine-3-carbonitrile", Chem. Heterocycl. Comp.,
45: 1226-1234, 2009.
 T. Mossman, "Rapid colorimetric assay for cellular growth and
survival: application to proliferation and cytotoxicity assays", J.
Immunol. Methods, 65: 55-63, 1983.
 Ramanathan R, Das NP, Tan CH (1994) Effects of -y-linolenic acid,
flavonoids, and vitamins on cytotoxicity and lipid peroxidation. Free
Rad Biol Med 16: 43-48
 J. Roth and G.E.P. De Souza, "Fever induction pathways: evidence
from responses to systemic or local cytokine formation", Braz. J. Med.
Biol. Res., 34:301-314, 2001.
 H.M. Kim, D.K. Ryu, Y. Choi, B.W. Park, K. Lee, S.B. Han, C. Lee,
M.R. Kang, J.S. Kang, S.K. Boovanahalli, S. Park, J.W. Han, T. Chun,
H.Y. Lee, K. Nam, E.H. Choi and G. Han, "Structure -activity
relationship studies of a series of novel ╬│-Lactam- based histone
deacetylase inhibitors", J. Med. Chem., 50:2737-2741, 2007.
 J.J. Mond, A. Balapure, N. Feuerstein, J.H. June, M. Brunswick, M.L.
Lindsberg and K. Witherspoon, "Protein kinase C activation in B cells
by indolactam inhibits anti-Ig- mediated phosphatidylinositol
bisphosphate hydrolysis but not B cell proliferation", J. Immunology,
 M.P. Zanni, S.V. Greyerz, B. Schnyder, C.K. Brander, K. Frutig, Y.
Hari, S. Valitutti and W.J. Pichler, "HLA-restricted, Processing- and
Metabolism-independent Pathway of Drug Recognition by Human ╬▒βT
Lymphocytes", J. Clin. Invest., 102:1591-1598, 1998.
 D.A. Hildeman, T. Mitchell and T.K. Teague, "Reactive oxygen species
regulate activation-induced T cell apoptosis", Immunity, 10:735-744,
 A. Fico, F. Paglialunga, L. Cigliano, P. Abrescia, P. Verde,
G. Martini, I. Iaccarino and S. Filosa, "Glucose-6-phosphate
dehydrogenase plays a crucial role in protection from redox-stressinduced
apoptosis", Cell Death Different., 11:823-831, 2004.
 B. Frossi, M. De Carli, M. Piemonte and C. Pucillo, "Oxidative
microenvironment exerts an opposite regulatory effect on cytokine
production by Th1 and Th2 cells", Mol. Immunology, 45:58-64, 2008.
 C. Y. Lee and J.M. Wan , "Vitamin E supplementation improves cellmediated
immunity and oxidative stress of Asian men and women" , J.
Nutr., 130: 2932-2937, 2000.
 X.H. Wang, X.Q. Zhou, J.P. Xu, Y. Wang and J. Lu, "The effects of
vitamin E on NK cell activity and lymphocyte proliferation in treated
mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin", Immunopharmacol.
Immunotoxicol., 1-7, 2009.
 L. Alpsoy, A. Yildirim and G. Agar, "The antioxidant effects of vitamin
A, C, and E on aflatoxin B1-induced oxidative stress in human
lymphocytes", Toxicol. Ind. Health, 25: 121-127, 2009.