Vincristine-Dextran Complex Loaded Solid Lipid Nanoparticles for Drug Delivery to the Brain
The purpose of this work was to inspect the potential
of vincristine-dextran complex loaded solid lipid nanoparticles for
drug delivery to the brain.
The nanoparticles were stained with a fluorescence dye and their
plasma pharmacokinetic and brain concentrations were investigated
following injection to rats.
The result revealed a significant improvement in the plasma
concentration profile of the SLN injected animals as well as a sharp
increased concentration in the brains.
Brain, Coumarin-6, Nanoparticles, SLN.